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KMID : 0362919940120030331
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Journal of the Korean Society for Therapeutic Radiology and Oncology
1994 Volume.12 No. 3 p.331 ~ p.336
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Local Control after Radiation Therapy for T1-T2 Glottic Carcinoma
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Kwon Byung-Hyun
Kim Dong-Won
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Abstract
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Purpose: To assess the effectiveness and problems of the primary radiation therapy and salvage surgery in a series of patients affected by T1-T2 NO glottic cancers treated from 1985 to 1991 at the Pusan National University Hospital.
Materials and Methods: From 8.85 to 12/91, 34 patients affected by early glottic carcinoma histologically proven were treated with curative radiation therapy. Distribution of patients according to T stage was 30 for T1 and 4 T2. Male to female ratio was 33:1. Age of patients ranged from 31 to 73 with mean age of 58 years. All of the patients were treated with radical radiation with total tumor dose of 63-75. 3 Gy(median 68.2 Gy), of 5 weekly fractions of 1.8-2Gy and with 6MV photon beams through two laterally opposed fields.
Results: The overall 5-year local control rates were 74%(8/30) for T1, and 25%(3/4) for T2. The main cause of failure was progression or recurrence in T(10/11). One failures were observed in T and N at the same time. Of these 11 patients, 9(81%) were salvaged with surgery. After surgical salvage of radiation failures, the 5-year survival rates were 96% for T1 and 75% T2. Among the survivors, 73% of T1 and 33% of T2 were able to preserve the larynx.
Conclusion: It can be concluded that radiotherapy is the first choice in the treatment of glottic T1 carcinoma.
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KEYWORD
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glottic carcinoma, radiation therapy, local control
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